A new adenine-substituted bromotyrosine-derived metabolite designated as aphrocallistin (1) has been isolated from the deep-water Hexactinellida sponge Aphrocallistes beatrix. Its structure was elucidated on the basis of spectral data and confirmed through a convergent, modular total synthetic route that is amenable toward future analogue preparation.
This document is the accepted manuscript version of a published work that appeared in final form in Journal of Natural Products after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/np900183v. This article may be cited as: Wright, A. E., Roth, G. P., Hoffman, J. K., Divlianska, D. B., Pechter, D., Sennett, S. H., Guzman, E. A., Linley, P., McCarthy, P. J., Pitts, T. P., Pomponi, S. A., & Reed, J K. (2009). Isolation, synthesis, and biological activity of Aphrocallistin, an adenine-substituted bromotyramine metabolite from the hexactinellida sponge Aphrocallistes beatrix. Journal of Natural Products, 72(6), 1178-1183. doi:10.1021/np900183v
Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #1733.