Isolation and structure elucidation of Perthamide B, a novel peptide from the sponge Theonella sp.

Member of
HBOI Faculty Contributions
Contributors
Gulavita, N. K.
Pomponi, Shirley A.
Wright, Amy E.
Yarwood, Donna
Sills, Matthew A.
Publisher
Elsevier B.V.
Date Issued
1994
Note

A sponge of the genus Theonella collected off Perth, Australia, contained a cyclic octapeptide, perthamide B, which weakly inhibited the binding of [125I]IL-1β to intact EL4.6.1 cells with an IC50 of 27.6 μM. The inhibition of binding could however, not be separated from the cytotoxic effects of perthamide B. The structure was elucidated by spectroscopic methods. A cyclic octapeptide perthamide B, which weakly inhibited the binding of [125I]IL-1β to intact EL4.6.1 cells with an IC50 of 27.6 μM, was isolated from a Theonella sp.

Language
English
Type
Text
Genre
article
Extent
5 p.
Subject (Topical)
Sponges
Cyclic peptides
Peptides--Structure
Spectroscopic techniques
Identifier
3331880
Additional Information
A sponge of the genus Theonella collected off Perth, Australia, contained a cyclic octapeptide, perthamide B, which weakly inhibited the binding of [125I]IL-1β to intact EL4.6.1 cells with an IC50 of 27.6 μM. The inhibition of binding could however, not be separated from the cytotoxic effects of perthamide B. The structure was elucidated by spectroscopic methods. A cyclic octapeptide perthamide B, which weakly inhibited the binding of [125I]IL-1β to intact EL4.6.1 cells with an IC50 of 27.6 μM, was isolated from a Theonella sp.
This manuscript is an author version with the final publication available at http://www.sciencedirect.com/science/journal/00404039 and may be cited as: Gulavita, N. K., Pomponi, S. A., Wright, A. E., Yarwood, D., & Sills, M. A. (1994). Isolation and structure elucidation of Perthamide B, a novel peptide from the sponge Theonella sp. Tetrahedron Letters, 35(37), 6815-6818. doi:10.1016/0040-4039(94)85012-7
Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #1047.
Date Backup
1994
Date Text
1994
DOI
10.1016/0040-4039(94)85012-7
Date Issued (EDTF)
1994
Extension


FAU
FAU
admin_unit="FAU01", ingest_id="ing11828", creator="creator:BCHANG", creation_date="2012-01-12 08:05:14", modified_by="super:FAUDIG", modification_date="2014-02-13 08:25:53"

IID
FADT3331880
Issuance
single unit
Person Preferred Name

Gulavita, N. K.

creator

Physical Description

pdf
5 p.
PURL
http://purl.flvc.org/FCLA/DT/3331880
Title Plain
Isolation and structure elucidation of Perthamide B, a novel peptide from the sponge Theonella sp.
URL
http://purl.flvc.org/FCLA/DT/3331880
Origin Information

Elsevier B.V.
1994
single unit
Title
Isolation and structure elucidation of Perthamide B, a novel peptide from the sponge Theonella sp.
Other Title Info

Isolation and structure elucidation of Perthamide B, a novel peptide from the sponge Theonella sp.