Brianthein V, a new cytotoxic and antiviral diterpene isolated from Briareum asbestinum

Member of
HBOI Faculty Contributions
Contributors
Coval, S. J.
Cross, S. S.
Bernardinelli, G.
Jefford, C. W.
Publisher
The American Chemical Society and American Society of Pharmacognosy
Date Issued
1988
Note

The gorgonian coral Briareum asbestinum (Pallas) (Briareidae), occurring in Caribbean waters, contains diterpenes of two skeletal types, the asbestinins and the briareins, some of which are endowed with biological activity (1, 2). Several chlorinated briareins have also been isolated, and the absolute structure of one of them, briarein A [1], a pentaacetate, has been determined by X-ray (3). Subsequently, a related species Briareum polyanthes, found off Bermuda, was examined. Three metabolites possessing the epoxybriarein structure, but designated as briantheins X [2], Y [3], and Z [4] were identified (4, 5). [The structure of Brianthein W, a less fuctionalized nonchlorinated briarein, has been recently determined (6).]

Language
English
Type
Text
Genre
article
Extent
5 p.
Subject (Topical)
Corals--Caribbean Sea
Gorgonacea
Diterpenes
Antiviral agents
Cytotoxin
Identifier
3332954
Additional Information
The gorgonian coral Briareum asbestinum (Pallas) (Briareidae), occurring in Caribbean waters, contains diterpenes of two skeletal types, the asbestinins and the briareins, some of which are endowed with biological activity (1, 2). Several chlorinated briareins have also been isolated, and the absolute structure of one of them, briarein A [1], a pentaacetate, has been determined by X-ray (3). Subsequently, a related species Briareum polyanthes, found off Bermuda, was examined. Three metabolites possessing the epoxybriarein structure, but designated as briantheins X [2], Y [3], and Z [4] were identified (4, 5). [The structure of Brianthein W, a less fuctionalized nonchlorinated briarein, has been recently determined (6).]
This document is the accepted manuscript version of a published work that appeared in final form in Journal of Natural Products after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/np50059a031. This article may be cited as: Coval, S. J., Cross, S., Bernardelli, G., & Jefford, C. W. (1988). Brianthein V, a new cytotoxic and antiviral diterpene isolated from Briareum asbestinum. Journal of Natural Products, 51(5), 981-984. doi.10.1021/np50059a031
Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #674.
Date Backup
1988
Date Text
1988
DOI
10.1021/np50059a031
Date Issued (EDTF)
1988
Extension


FAU
FAU
admin_unit="FAU01", ingest_id="ing12076", creator="creator:BCHANG", creation_date="2012-02-22 07:46:12", modified_by="super:FAUDIG", modification_date="2014-02-13 10:30:20"

IID
FADT3332954
Issuance
single unit
Organizations
Attributed name: Harbor Branch Oceanographic Institute
Person Preferred Name

Coval, S. J.

creator

Physical Description

pdf
5 p.
PURL
http://purl.flvc.org/FCLA/DT/3332954
Title Plain
Brianthein V, a new cytotoxic and antiviral diterpene isolated from Briareum asbestinum
URL
http://purl.flvc.org/FCLA/DT/3332954
Origin Information

The American Chemical Society and American Society of Pharmacognosy
1988
single unit
Title
Brianthein V, a new cytotoxic and antiviral diterpene isolated from Briareum asbestinum
Other Title Info

Brianthein V, a new cytotoxic and antiviral diterpene isolated from Briareum asbestinum