Chemistry and biology of the discodermolides, potent mitotic spindle poisons

(+)-Discodermolide (1) is a highly functionalized, marine sponge-derived polyketide 8-lactone presumably formed by a combination of propionate and acetate units. 1 was first isolated and characterized by Gunasekera et al. [ at the Harbor Branch Oceanographic Institution (HBOI) from the marine sponge Discodermia dissoluta Crude extracts of the sponge showed strong potency against the murine P388 lymphocytic leukemia cell line, and bioassay-guided fractionation using this assay resulted in the purification of 1.

This is an electronic published version of an article which may be cited as: Gunasekera, S. P., & Wright, A. E. (2005). Chemistry and biology of the discodermolides, potent mitotic spindle poisons. In G. M. Cragg, D. G. I. Kingston, & D. J. Newman (eds.), Anticancer Agents from Natural Products. (pp. 171-189). Boca Raton, FL: Taylor & Francis.

Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #1603.

Date Backup

2005

Date Text

2005

DOI

10.1201/b11185-11

Date Issued (EDTF)

2005

Extension

FAU
FAU
admin_unit="FAU01", ingest_id="ing13685", creator="creator:BCHANG", creation_date="2012-09-26 09:16:16", modified_by="super:FAUDIG", modification_date="2014-02-19 08:57:10"

IID

FADT3352941

Issuance

single unit

Person Preferred Name

Gunasekera, Sarath P.

creator

Physical Description

pdf
34 p.

PURL

http://purl.flvc.org/FCLA/DT/3352941

Title Plain

Chemistry and biology of the discodermolides, potent mitotic spindle poisons

URL

http://purl.flvc.org/FCLA/DT/3352941

Origin Information

Taylor & Francis Group
2005
single unit

Title

Chemistry and biology of the discodermolides, potent mitotic spindle poisons

Other Title Info

Chemistry and biology of the discodermolides, potent mitotic spindle poisons