Note
Thesis (B.S.)--Florida Atlantic University, Harriet L. Wilkes Honors College, 2023
Member of
Publisher
Florida Atlantic University
Date Issued
2023
EDTF Date Created
2023
Description
Alzheimer's Disease (AD) is the most common neurodegenerative disease worldwide. It is characterized by the formation of amyloid plaques and neurofibrillary tangles, leading to cognitive decline and memory deficiencies. Exercise has been shown to induce neurogenesis within the dentate gyrus of the hippocampus. However, the effects that exercise has on neuronal morphology are not fully understood. In this preliminary study I used APPswe/PSEN1dE9 mice, a mouse model of AD, to quantify the morphological changes caused by exercise in the mice via access to a running wheel. The results showed that exercise caused significant morphological changes in the brains of females but not males. These findings increase our knowledge of the role exercise may have as a therapeutic and provide insight into the importance of sex differences regarding potential therapeutics for those with AD.
Language
Type
Genre
Form
Extent
46 p.
Identifier
FAUHT00273
Rights
Copyright © is held by the author with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder.
Additional Information
Thesis (B.S.)--Florida Atlantic University, Harriet L. Wilkes Honors College, 2023
Date Backup
2023
Date Created Backup
2023
Date Text
2023
Date Created (EDTF)
2023
Date Issued (EDTF)
2023
Extension
FAU
IID
FAUHT00273
Organizations
Attributed name: Florida Atlantic University
Person Preferred Name
Schwab, Jason
author
Harriet L. Wilkes Honors College
Physical Description
application/pdf
46 p.
Title Plain
THE EFFECTS OF EXERCISE AND SEX DIFFERENCES ON THE MORPHOLOGY OF HIPPOCAMPAL NEURONS IN A MOUSE MODEL OF ALZHEIMER’S DISEASE
Use and Reproduction
Copyright © is held by the author with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder.
http://rightsstatements.org/vocab/InC/1.0/
Origin Information
2023
2023
Florida Atlantic University
Jupiter, FL
Place
Jupiter, FL
Title
THE EFFECTS OF EXERCISE AND SEX DIFFERENCES ON THE MORPHOLOGY OF HIPPOCAMPAL NEURONS IN A MOUSE MODEL OF ALZHEIMER’S DISEASE
Other Title Info
THE EFFECTS OF EXERCISE AND SEX DIFFERENCES ON THE MORPHOLOGY OF HIPPOCAMPAL NEURONS IN A MOUSE MODEL OF ALZHEIMER’S DISEASE