In the course of screening for novel bioactive agents from marine sponges, we have isolated from the Caribbean sponge Ptilocaulis spiculifer and from a red Hemimycale sp. of the Red Sea the same antitumor, antiviral, and antifungal compound designated ptilomycalin A, (1), 2 which possesses a unique polycyclic guanidine structure.
This document is the accepted manuscript version of a published work that appeared in final form in Journal of the American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/ja00206a029. This article may be cited as: Kashman, Y., Hirsh, S., McConnell, O. J., Ohtani, I., Kusumi, T., & Kakisawa, H. (1989). Ptilomycalin A: a novel polycyclic guanidine alkaloid of marine origin. Journal of the American Chemical Society, 111(24), 8925-8926. doi:10.1021/ja00206a029
Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #752.