Note
Includes bibliography.
Member of
Contributors
Publisher
Florida Atlantic University
Date Issued
2018
EDTF Date Created
2018
Description
This research is part of a long-term project aimed at elucidating important structural
features, of both ligands and metals, that are needed to produce effective anti-cancer agents.
The specific goal is the synthesis of organotin polymers containing amino acids, in this
case the diamino acid diglycine. The desired materials were synthesized with percent yields
ranging from 32-99%. The products were synthesized employing the interfacial
polymerization technique. The polymers were then characterized utilizing the following
physical characterization techniques: light scattering photometry (LS), Infrared
spectroscopy (IR), nuclear magnetic resonance spectroscopy (NMR), and matrix assisted
laser desorption mass spectroscopy (MALDI). Physical characterization showed evidence
of formation of desired adducts in addition to data that was consistent with the formation
of materials containing multiple repeat units. The materials were then analyzed for
biological activity. The synthesized materials displayed the ability to inhibit tested cancer
cell lines.
features, of both ligands and metals, that are needed to produce effective anti-cancer agents.
The specific goal is the synthesis of organotin polymers containing amino acids, in this
case the diamino acid diglycine. The desired materials were synthesized with percent yields
ranging from 32-99%. The products were synthesized employing the interfacial
polymerization technique. The polymers were then characterized utilizing the following
physical characterization techniques: light scattering photometry (LS), Infrared
spectroscopy (IR), nuclear magnetic resonance spectroscopy (NMR), and matrix assisted
laser desorption mass spectroscopy (MALDI). Physical characterization showed evidence
of formation of desired adducts in addition to data that was consistent with the formation
of materials containing multiple repeat units. The materials were then analyzed for
biological activity. The synthesized materials displayed the ability to inhibit tested cancer
cell lines.
Language
Type
Form
Extent
120 p.
Subject (Topical)
Identifier
FA00013158
Additional Information
Includes bibliography.
Thesis (M.S.)--Florida Atlantic University, 2018.
FAU Electronic Theses and Dissertations Collection
Date Backup
2018
Date Created Backup
2018
Date Text
2018
Date Created (EDTF)
2018
Date Issued (EDTF)
2018
Extension
FAU
IID
FA00013158
Organizations
Attributed name: Florida Atlantic University
Attributed name: Charles E. Schmidt College of Science
Attributed name: Department of Chemistry and Biochemistry
Person Preferred Name
Slawek, Paul Peter
author
Graduate College
Physical Description
application/pdf
120 p.
Title Plain
Synthesis and Characterization of Organotin Polyamine Esters from Diglycine
Use and Reproduction
Copyright © is held by the author with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder.
http://rightsstatements.org/vocab/InC/1.0/
Origin Information
2018
2018
Florida Atlantic University
Boca Raton, Fla.
Physical Location
Florida Atlantic University Libraries
Place
Boca Raton, Fla.
Sub Location
Digital Library
Title
Synthesis and Characterization of Organotin Polyamine Esters from Diglycine
Other Title Info
Synthesis and Characterization of Organotin Polyamine Esters from Diglycine