Note
Includes bibliography.
Member of
Contributors
Publisher
Florida Atlantic University
Date Issued
2023
EDTF Date Created
2023
Description
Prostate cancer, the most frequent non-skin cancer, is the second leading cause of cancer-related deaths in males within the United States. Men diagnosed with metastatic prostate cancer have a 5-year survival rate of approximately 30%. Goals of this study were to produce a combination of compounds that are effective against the disease with minimal side effects on normal cells, especially those of the immune system.
This study showed KBU2046 in combination with calcitriol, limit proliferation, inhibit migration, and are cytotoxic in a testosterone dependent human prostate cancer cell line. Organic compounds, ellagic acid and curcumin were tested alone and in combination with either calcitriol or KBU2046. No combinations were as effective as KBU2046 and calcitriol in inhibiting migration and proliferation of LNCaP cells.
The findings of this study support further investigation into therapeutic use of a combination of KBU2046 and calcitriol in prevention and remission of human prostate cancer.
This study showed KBU2046 in combination with calcitriol, limit proliferation, inhibit migration, and are cytotoxic in a testosterone dependent human prostate cancer cell line. Organic compounds, ellagic acid and curcumin were tested alone and in combination with either calcitriol or KBU2046. No combinations were as effective as KBU2046 and calcitriol in inhibiting migration and proliferation of LNCaP cells.
The findings of this study support further investigation into therapeutic use of a combination of KBU2046 and calcitriol in prevention and remission of human prostate cancer.
Language
Type
Form
Extent
102 p.
Subject (Topical)
Identifier
FA00014242
Rights
Copyright © is held by the author with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder.
Additional Information
Includes bibliography.
Thesis (MS)--Florida Atlantic University, 2023.
FAU Electronic Theses and Dissertations Collection
Date Backup
2023
Date Created Backup
2023
Date Text
2023
Date Created (EDTF)
2023
Date Issued (EDTF)
2023
Extension
FAU
IID
FA00014242
Organizations
Attributed name: Florida Atlantic University
Attributed name: Department of Biological Sciences
Attributed name: Charles E. Schmidt College of Science
Person Preferred Name
Yi, Zoey
author
Graduate College
Physical Description
application/pdf
102 p.
Title Plain
Inhibition of the Growth and Spread of Human Prostate Cancer
Use and Reproduction
Copyright © is held by the author with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder.
Origin Information
2023
2023
Florida Atlantic University
Boca Raton, Fla.
Place
Boca Raton, Fla.
Title
Inhibition of the Growth and Spread of Human Prostate Cancer
Other Title Info
Inhibition of the Growth and Spread of Human Prostate Cancer