Two new five-membered-ring peroxide acids, plakinic acid F (3) and epiplakinic acid F (4), and a new peroxide−lactone, plakortolide F (5), were isolated from a sponge of the genus Plakinastrella collected from Felicite Island, Seychelles. The structures were elucidated through spectral analysis. The free acids 3 and 4 exhibit moderate antifungal activity against Candida albicans with minimum inhibitory concentrations of 25 μg/mL (SDB) and 3.1 μg/mL (RPMI) for 3, and 25 μg/mL (SDB) and 6.25 μg/mL (RPMI) for 4, respectively.
This document is the accepted manuscript version of a published work that appeared in final form in Journal of Natural Products after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/np000368+. This article may be cited as: Chen, Y. K., Killday, B., McCarthy, P. J., Schimoler, R., Chilson, K., Selitrennikoff, C., Pomponi, S. A., & Wright, A. E. (2001). Three new peroxides from the sponge Plakinastrella species. Journal of Natural Products, 64(2), 262-264. doi:10.1021/np000368+
Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #1392.