Metabolic syndrome -- Pathophysiology

The purpose of this study was to examine the acute and temporal response of CK- MM and FGF-21 to 3-day/wk. different repetition-range, volume-equated resistance training programs over 8-weeks in previously trained males. Sixteen trained, college- aged males were counterbalanced into high (DUP-HR) or low (DUP-LR) repetition groups. Subjects performed the squat and bench press 3x/wk. for 8 weeks. Blood samples were collected at various intervals throughout the study. Trained individuals did not elicit significant acute or chronic changes in CK-MM or FGF-21 following training and the lack of change was present in both groups. Additionally, neither biomarker correlated with changes in 1RM strength. There was a very strong correlation between acute mean (r=0.95) and acute percentage change (r=0.97) increase from pre training to post training in week #1. Additionally, a moderate correlation in percentage change was observed (r=0.59) of both biomarkers from pre training to 48 hours post training in week #2.

The purpose of this study was to determine if resistance exercise altered
peripheral BDNF concentration. Eighteen trained male subjects were split into two
groups performing varied repetition ranges. DUP-HR and DUP-LR groups trained
3x/week for 8 weeks, and were equated for total volume (repetitions X sets X intensity).
Plasma BDNF and interleukin-6 (IL-6) levels were measured prior to and immediately
following the first exercise session of weeks 1, 2, 4 and 6. Pre-exercise levels were also
assessed prior to the second and third sessions of week 1 and 6. Lastly, resting levels
were measured before and after training intervention. No group differences (p>0.05) were detected for either biomarker. An acute BDNF elevation (p=0.018) was detected only in the final week of training. IL-6 elevations were detected at all acute measurements (p<0.01). BDNF and IL-6 percentage change correlated significantly (p<0.05) in week-1. No chronic alterations were observed (p>0.05).