Treatment

Fidgeting and otherwise constant movements in individuals can be beneficial in those who suffer from Attention Deficit/Hyperactivity Disorder or Generalized Anxiety Disorder as well as others. However this constant movement can also be a distraction to others as well as protrude an air of no self confidence. It is the drawbacks from these actions that we wish to address. By developing an intelligent system that can detect these motions and alert the user, it will allow the wearer of the device to self correct. It is in this self control that one may exhibit more confidence or simply reduce the level of irritation experienced by those in the immediate vicinity. We have designed and built a low cost, mobile, lightweight, untethered, wearable prototype device. It will detect these actions and deliver user selectable biofeedback through a light emitting diode, buzzer, vibromotor or an electric shock to allow for self control.

Recent research has provided evidence that speech-related visual feedback presented to people who stutter may enhance fluency as effectively as well-established forms of altered auditory feedback. This study aimed to explore the effectiveness of visual feedback during speaking conditions that approximated naturalistic conversation. In order to determine what aspects of visual feedback may contribute to fluency enhancement, the feedback was manipulated in terms of synchronicity and linguistic congruence to the original signal. Participants included ten adults diagnosed with developmental stuttering with no concurring conditions. The study consisted of the following four conditions: synchronous visual feedback, asynchronous visual feedback, non-speech related visual feedback, and a control condition. Speech samples were analyzed for the percent of syllables stuttered per condition. Upon analysis of data, no statistically significant effect of visual feedback was found on stuttering frequency, although individual results varied greatly.

In this study the effectiveness of WatchMinderTM, a vibrating prompt watch, was examined as a component of a self-monitoring intervention package to help students with autism increase on-task behavior during independent seatwork. A multitude of literature since the 1970s has suggested that self-monitoring interventions are integral in increasing task engagement. Tactile prompting devices are a new aspect of self-monitoring interventions, and the limited research has shown that these unobtrusive devices are effective for providing feedback to monitor their behavior. Self-graphing is another component of self-monitoring interventions that has received little attention in the literature. However, many studies recognize the importance for individuals to be active participants in their educational programs by analyzing progress and being a part of the decision making process. This study assessed the use of WatchMinder and self-graphing on the on-task behavior of four elementary students with autism in the special education setting.

Cone snails are carnivorous marine mollusks, utilizing their neuropeptide-rich venom for prey capture. The venom of Conus brunneus, a wide-spread Eastern Pacific vermivore, has not been extensively studied. In the current work, peptides from the dissected venom were characterized and tested using preliminary bioassays. Six peptides (A-F) were isolated and tested. Three peptide identities were determined by comparison with previously reported data: bru9a (A), bru3a (F), and an a-conotoxin (E). Preliminary screening in a stroke-related model of induced glutamate excitotoxicity in primary neuronal cells and PC12 cell cultures indicated potential neuroprotective activity of peptide fractions A, D, and F. Further testing is necessary to determine and verify structure, activity, target, and mechanism of action of the promising peptides from C. brunneus, which may prove effective neuropharmacological agents to treat stroke.

The role of attachment style in overall family functioning and in individual substance abuse patterns has been researched extensively. Lifestyle constructs have been seen as predictors of substance abuse related behaviors, including future drug related difficulties. Dysfunctional family environments have been seen as predictors of poor mental health outcomes in family members. Despite the high rates of co-morbidity in alcohol and drug dependent individuals, parental lifestyle, attachment style, and the overall influence of family environment on the psychological traits of substance dependent individuals had not been previously examined. This study examined a group of parents and their adult children (actively in substance abuse treatment, with diagnoses of substance dependence) who participated in a weeklong family education program at an inpatient treatment center. Direct effects were found between attachment style, lifestyle and patient traits, as well as several significant total effects (combined direct effect and the effect of overall family environment). Specific indirect effects were also found from individual family environment mediators, including moral religious emphasis and control, on the relationship between independent and dependent variables. An analysis of the results is given, along with a discussion of clinical implications and directions for future research.

individuals who self-identify as sex addicts, unique health and social consequences are not well understood because of factors, such as stigma. It is important that the nursing community understand this phenomenon to address, understand, and provide sensitive and meaningful care. However, there is limited research on this topic. The purpose of this study was to explore the lived experience of individuals who self-identify as sex addicts. Through snowball sampling, five men and five women between 27 to 45 years old, and older. participated in the phenomenological study. Meaning units and themes were revealed through the participants' experiences as follows: A Connecting with Others: 1. Reaching Out 2. Seeking Shared Understanding 3. Connecting with Your Higher Power B Managing Stigma: 1. Revealing Concealing C Integrating the Past for Recovery: 1. Reflecting Triggers 2. Overcoming Powerlessness. D Being Vigilant: 1. Intentional Refocusing 2. Living an Honest Life E Giving of Oneself: 1. Informing Others 2. Doing Service. The overall structure synthesized from the meaning units and themes was: "The lived experience of seeking health in recovery from sex addiction is dancing on the outer circle, connected to a community that understands fear, shame and the struggle to remain vigilant for pitfalls while intentionally refocusing on living an honest life of giving and receiving." Seeking health incorporates a holistic, community involved, multifaceted approach to recovery. Understanding how individuals seek health in recovery provides a framework to impart meaningful, sensitive nursing care.

Diabetic retinopathy is an ischemic retinal neovascular disease causing vision loss among adults. The studies presented involve the design and testing of a gene therapy vector to inhibit retinal revascularization, similar to that found in diabetic retinopathy. Gene therapy has proven to be an effective method to introduce therapeutic proteins to treat retinal diseases. Targeting a specific cell type and expression of therapeutic proteins according to the tissue microenvironment should have an advantage over traditional gene therapy by avoiding unwanted transgene expression. Hypoxia plays a significant role in the pathophysiology of many retinal ischemic diseases. Retinal Mèuller cells provide structural and functional support to retinal neurons, as well as playing a significant role in retinal neovascularization. Targeting Mèuller cells may be an effective strategy to prevent retinal neovascularization under pathological conditions. ... The hypoxia regulated, glial specific vector successfully reduced the abnormal neovascularization in the periphery by 93% and reduced the central vasobliterated area by 90%. A substantial amount of exogenous endostatin was produced in the retinas of P17 OIR mice. A significant increase in human endostatin protein and reduced vascular endothelial growth factor (VEGF) were identified by Western blot and ELISA, respectively. These findings suggest hypoxia-regulated, glial cell-specific scAAV mediated gene expression may be useful to prevent blindness found in devastating retinal diseases involving neovascularization.

Autism Spectrum Disorders (ASD) affects one in every 110 children. Medical and educational research have demonstrated that ASD children's social skills and adaptation can be much improved, provided that interventions are early and intensive enough. The advancement of computer technologies and their ubiquitous penetration in people's life make them widely available to support intensive sociocognitive rehabilitation. Additionally, computer interactions are a natural choice for people with autism who value lawful and "systematizing" tools. A number of computer-aided approaches have been developed, showing effectiveness and generalization, but little quantitative research was conducted to identify the critical factors of engaging and improving the child's interest and performance. This thesis designs an adaptive computer interaction system, called Ying, which detects learning patterns in children with ASD and explores the computer interactive possibilities. The system tailors its content based on periodic performance assessments that offer a more effective learning path for children with ASD.

Wigging Out, a memoir, chronicles my first chemotherapy treatment which began in 2008 for the autoimmune disease Lupus. The primary focus is on how identity is affected by disability. Each symptom of my disease and side effect from my medications prompted a reevaluation of my identity as I felt a change both in myself and in the way others perceived me. In order to maintain a sense of control, I tried several techniques to pass and cover my disabled status, including the use of prosthetic hair pieces. Ultimately, the use of prosthetics made accepting my situation more difficult as it encouraged holding onto a former identity rather than creating a new one. It was not until I stopped using prosthetics as a form of denial and instead adopted them as part of a new identity that I was finally able to achieve the confidence necessary to fight for my life.

The implantable cardioverter defibrillator (ICD) is an electronic medical device that was invented by Dr. Michael Mirowski and his team in 1980. The purpose of the ICD, which is implanted in a person's chest, is to sense and shock the heart when detecting a lethal cardiac arrhythmia into a rhythm that can sustain life. While the ICD saves lives, it also has the potential to deliver painful shocks when it is activated. The ICD was initially inserted in people who had survived a sudden cardiac arrest; the device is now being implanted in older adults with heart failure and no known history of cardiac arrhythmias. When talking with patients and personal family members who had an ICD, it was unclear what influenced their decision to have an ICD implanted. Understanding the experience of decision-making for older adults who had an ICD has added to nursing knowledge, practice, and education when working with people who had an ICD inserted. To understand the lived experience, the researcher conducted a phenomenological research study, guided by the theoretical lens of Paterson and Zderad's (1976/1988) humanistic nursing and analyzed the data as outlined by Giorgi (2009). The results of the study indicated the participants' lived experience of decision-making for older adults who had an implantable cardioverter defibrillator inserted was influenced by the following : trust in their physician's decision; accepting the device was necessary; the decision was easy to make; and hope and desire to live longer.