Model
Digital Document
Publisher
Florida Atlantic University
Description
The primary purpose of this study was to investigate the effects of aerobic and
resistance training on BDNF and IGF-I expression in a 3xTg-AD mouse model of
Alzheimer’s disease. Twenty-four 3xTg-AD mice were randomly assigned to either an
aerobic (AT, n=8), resistance (RT, n=8), or control (CNT, n=8) group. Intervention
groups underwent 9 weeks of exercise training. Motor behavior and grip strength were
measured pre- and post- intervention. Our results showed a significant increase in
hippocampal BDNF expression in AT mice after a 9-week intervention. Further, AT mice
were found to have higher concentrations of IGF-I, and improved motor behavior when
compared to RT and CNT. No significant differences were observed in IGF-I
concentration between RT and other groups. RT improved grip strength after nine weeks
of training. These findings support the use of AT and RT as a tool to improve
comorbidities found in Alzheimer’s disease.
resistance training on BDNF and IGF-I expression in a 3xTg-AD mouse model of
Alzheimer’s disease. Twenty-four 3xTg-AD mice were randomly assigned to either an
aerobic (AT, n=8), resistance (RT, n=8), or control (CNT, n=8) group. Intervention
groups underwent 9 weeks of exercise training. Motor behavior and grip strength were
measured pre- and post- intervention. Our results showed a significant increase in
hippocampal BDNF expression in AT mice after a 9-week intervention. Further, AT mice
were found to have higher concentrations of IGF-I, and improved motor behavior when
compared to RT and CNT. No significant differences were observed in IGF-I
concentration between RT and other groups. RT improved grip strength after nine weeks
of training. These findings support the use of AT and RT as a tool to improve
comorbidities found in Alzheimer’s disease.
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