Model
Digital Document
Publisher
Florida Atlantic University
Description
Precise axon termination is necessary for the development of a functioning neuronal
network within the nervous system. However, little is known about the mechanisms that
regulate axon termination. C. elegans RPM-1, a conserved member of the PHR proteins,
has been previously shown to regulate axon termination and synapse formation. Recently,
it was shown that, when phosphorylated by Cdk5, CRMP-2 (the mammalian homolog of
C. elegans UNC-33) acts as a microtubule destabilizer during axon outgrowth. We
investigated the relationship between the RPM-1 and UNC-33 pathways in axon
termination. Our data has lead to the conclusion that the CDK-5, UNC-33 pathway works
in parallel with the RPM-1 pathway to regulate axon termination.
network within the nervous system. However, little is known about the mechanisms that
regulate axon termination. C. elegans RPM-1, a conserved member of the PHR proteins,
has been previously shown to regulate axon termination and synapse formation. Recently,
it was shown that, when phosphorylated by Cdk5, CRMP-2 (the mammalian homolog of
C. elegans UNC-33) acts as a microtubule destabilizer during axon outgrowth. We
investigated the relationship between the RPM-1 and UNC-33 pathways in axon
termination. Our data has lead to the conclusion that the CDK-5, UNC-33 pathway works
in parallel with the RPM-1 pathway to regulate axon termination.
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