Note
Includes bibliography.
Member of
Contributors
Publisher
Florida Atlantic University
Date Issued
2008
EDTF Date Created
2008
Description
In this thesis I studied propensity for behavioral sensitization to nicotine in
the LRHR phenotype and associated plasticity in the hippocampal mossy fiber
morphology. I also investigated therapeutic effects of bupropion and a
cannabinoid receptor antagonist on behavioral and morphological indices in
adolescence and adulthood. Male rats were classified into high responders (HR)
and low responders (LR) based on their locomotor response to a novel
environment. LRHR animals underwent behavioral sensitization to nicotine and
after one week of abstinence were challenged with a low dose of nicotine. HRs
expressed behavioral sensitization to nicotine and showed an increase in
hippocampal mossy fiber terminal field size. AM251 administration during
abstinence reversed behavioral sensitization in HRs and bupropion only
attenuated the locomotor response to na"ive nicotine exposure. Therapeutic
agents had differential effects on mossy fiber morphology dependent on
phenotype and age.
the LRHR phenotype and associated plasticity in the hippocampal mossy fiber
morphology. I also investigated therapeutic effects of bupropion and a
cannabinoid receptor antagonist on behavioral and morphological indices in
adolescence and adulthood. Male rats were classified into high responders (HR)
and low responders (LR) based on their locomotor response to a novel
environment. LRHR animals underwent behavioral sensitization to nicotine and
after one week of abstinence were challenged with a low dose of nicotine. HRs
expressed behavioral sensitization to nicotine and showed an increase in
hippocampal mossy fiber terminal field size. AM251 administration during
abstinence reversed behavioral sensitization in HRs and bupropion only
attenuated the locomotor response to na"ive nicotine exposure. Therapeutic
agents had differential effects on mossy fiber morphology dependent on
phenotype and age.
Language
Type
Form
Extent
100 p.
Subject (Topical)
Identifier
FA00000727
Additional Information
Includes bibliography.
Dissertation (Ph.D.)--Florida Atlantic University, 2008.
Charles E. Schmidt College of Medicine
FAU Electronic Theses and Dissertations Collection
Date Backup
2008
Date Created Backup
2008
Date Text
2008
Date Created (EDTF)
2008
Date Issued (EDTF)
2008
Extension
FAU
IID
FA00000727
Organizations
Attributed name: Florida Atlantic University
Person Preferred Name
Bhatti, Amrinder S.
Graduate College
Physical Description
application/pdf
100 p.
Title Plain
Behavioral sensitization to nicotine in the novelty-seeking phenotype and hippocampal mossy fiber morphology
Use and Reproduction
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Origin Information
2008
2008
Florida Atlantic University
Boca Raton, Fla.
Physical Location
Florida Atlantic University Libraries
Place
Boca Raton, Fla.
Sub Location
Digital Library
Title
Behavioral sensitization to nicotine in the novelty-seeking phenotype and hippocampal mossy fiber morphology
Other Title Info
Behavioral sensitization to nicotine in the novelty-seeking phenotype and hippocampal mossy fiber morphology