Model
Digital Document
Publisher
Florida Atlantic University
Description
In this thesis I studied propensity for behavioral sensitization to nicotine in
the LRHR phenotype and associated plasticity in the hippocampal mossy fiber
morphology. I also investigated therapeutic effects of bupropion and a
cannabinoid receptor antagonist on behavioral and morphological indices in
adolescence and adulthood. Male rats were classified into high responders (HR)
and low responders (LR) based on their locomotor response to a novel
environment. LRHR animals underwent behavioral sensitization to nicotine and
after one week of abstinence were challenged with a low dose of nicotine. HRs
expressed behavioral sensitization to nicotine and showed an increase in
hippocampal mossy fiber terminal field size. AM251 administration during
abstinence reversed behavioral sensitization in HRs and bupropion only
attenuated the locomotor response to na"ive nicotine exposure. Therapeutic
agents had differential effects on mossy fiber morphology dependent on
phenotype and age.
the LRHR phenotype and associated plasticity in the hippocampal mossy fiber
morphology. I also investigated therapeutic effects of bupropion and a
cannabinoid receptor antagonist on behavioral and morphological indices in
adolescence and adulthood. Male rats were classified into high responders (HR)
and low responders (LR) based on their locomotor response to a novel
environment. LRHR animals underwent behavioral sensitization to nicotine and
after one week of abstinence were challenged with a low dose of nicotine. HRs
expressed behavioral sensitization to nicotine and showed an increase in
hippocampal mossy fiber terminal field size. AM251 administration during
abstinence reversed behavioral sensitization in HRs and bupropion only
attenuated the locomotor response to na"ive nicotine exposure. Therapeutic
agents had differential effects on mossy fiber morphology dependent on
phenotype and age.
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