Discodermolide: a new bioactive polyhydroxylated lactone from the marine sponge Discodermia dissoluta

A new polyhydroxylated lactone, discodermolide (l), was isolated from a Caribbean marine sponge, Discodermia dissoluta, and its structure was elucidated through a combination of spectroscopic techniques, in particular NMR spectroscopy, and verified by X-ray crystallographic analysis. The carbon skeleton displayed by discodermolide is new; discodermolide is immunosuppressive and cytotoxic.

This document is the accepted manuscript version of a published work that appeared in final form in The Journal of Organic Chemistry after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/jo00303a029. This article may be cited as: Gunasekera, S. P., Gunasekera, M., Longley, R. E., & Schulte, G. K. (1990). Discodermolide: a new bioactive polyhydroxylated lactone from the marine sponge Discodermia dissoluta. The Journal of Organic Chemistry, 55(16), 4912-4915. doi:10.1021/jo00303a029

Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #767.