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Lactones

The microtubule-stabilizing agent discodermolide competitively inhibits the binding of paclitaxel (Taxol) to tubulin polymers, enhances tubulin nucleation reactions more potently than paclitaxel, and inhibits the growth of paclitaxel-resistant cells.

Model
Digital Document
Kowalski, R. J.
Giannakakou, P.
Gunasekera, Sarath P.
Longley, Ross E.
Day, B. W.
Hamel, E.
Publisher
American Society for Pharmacology and Experimental Therapeutics
Member of
HBOI Faculty Contributions

Discodermolide: a new bioactive polyhydroxylated lactone from the marine sponge Discodermia dissoluta

Model
Digital Document
Gunasekera, Sarath P.
Gunasekera, M.
Longley, Ross E.
Schulte, G. K.
Publisher
American Chemical Society
Member of
HBOI Faculty Contributions

Plakolide A, a New γ‐Lactone from the Marine Sponge Plakortis sp.

Model
Digital Document
Gunasekera, Sarath P.
Isbrucker, Richard A.
Longley, Ross E.
Wright, Amy E.
Pomponi, Shirley A.
Reed, John K.
Publisher
American Chemical Society and American Society of Pharmacognosy
Member of
HBOI Faculty Contributions
Lactones
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