The microtubule-stabilizing agent discodermolide competitively inhibits the binding of paclitaxel (Taxol) to tubulin polymers, enhances tubulin nucleation reactions more potently than paclitaxel, and inhibits the growth of paclitaxel-resistant cells. Model Digital Document Kowalski, R. J. Giannakakou, P. Gunasekera, Sarath P. Longley, Ross E. Day, B. W. Hamel, E. Publisher American Society for Pharmacology and Experimental Therapeutics Member of HBOI Faculty Contributions