Plakolide A (1), a new α-exomethylene-γ-lactone isolated from the marine sponge Plakortis sp., was found to inhibit inducible nitric oxide synthase (iNOS) activity. The isolation, structure elucidation, and biological activity of plakolide A is described.
This document is the accepted manuscript version of a published work that appeared in final form in Journal of Natural Products after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/np030294c. This article may be cited as: Gunasekera, S. P., Isbrucker, R. A., Longley, R. E., Wright, A. E., Pomponi, S. A., & Reed, J. K. (2004). Plakolide A, a New γ-Lactone from the Marine Sponge Plakortis sp. Journal of Natural Products, 67(1), 110-111.
Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #1536.