Note
Charles E. Schmidt College of Science
Member of
Contributors
Publisher
Florida Atlantic University
Date Issued
2007
EDTF Date Created
2007
Description
The current study uses a diabetic rat model to measure the effects of pulsatile
versus continuous insulin delivery on IRS-2 in the liver. The purpose is to determine if
pulsatile, compared with continuous, insulin delivery leads to reduced insulin resistance
in diabetic rats. Insulin signaling in the liver is mediated primarily through IRS-2 and
tissue responsiveness to insulin may be detected by monitoring the lRS-2 signaling
pathway. Western blots were performed to measure IRS-2 protein levels for each
delivery condition and treatment day. Results revealed that overall, the pulsatile insulin
delivery method showed a significant increase in IRS-2 levels over the continuous insulin
delivery method by treatment day 5. These findings imply that the pulsatile delivery
method, over a period of time, triggers more insulin receptor action. Conversely, the
results of the continuous delivery system show a decrease in IRS-2 levels as the number
of doses of insulin increased.
versus continuous insulin delivery on IRS-2 in the liver. The purpose is to determine if
pulsatile, compared with continuous, insulin delivery leads to reduced insulin resistance
in diabetic rats. Insulin signaling in the liver is mediated primarily through IRS-2 and
tissue responsiveness to insulin may be detected by monitoring the lRS-2 signaling
pathway. Western blots were performed to measure IRS-2 protein levels for each
delivery condition and treatment day. Results revealed that overall, the pulsatile insulin
delivery method showed a significant increase in IRS-2 levels over the continuous insulin
delivery method by treatment day 5. These findings imply that the pulsatile delivery
method, over a period of time, triggers more insulin receptor action. Conversely, the
results of the continuous delivery system show a decrease in IRS-2 levels as the number
of doses of insulin increased.
Language
Type
Form
Extent
34 p.
Subject (Topical)
Identifier
FA00000818
Additional Information
Charles E. Schmidt College of Science
Thesis (M.A.)--Florida Atlantic University, 2007.
Date Backup
2007
Date Created Backup
2007
Date Text
2007
Date Created (EDTF)
2007
Date Issued (EDTF)
2007
Extension
FAU
IID
FA00000818
Organizations
Attributed name: Florida Atlantic University
Person Preferred Name
Reis, Danielle
Graduate College
Physical Description
application/pdf
34 p.
Title Plain
Do The Dynamics of Insulin Delivery Matter for Management of Diabetes Mellitus? Evidence From Molecular Measures in a Diabetic Rat Model.
Use and Reproduction
Copyright © is held by the author with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder.
http://rightsstatements.org/vocab/InC/1.0/
Origin Information
2007
2007
Florida Atlantic University
Boca Raton, Fla.
Physical Location
Florida Atlantic University Libraries
Place
Boca Raton, Fla.
Sub Location
Digital Library
Title
Do The Dynamics of Insulin Delivery Matter for Management of Diabetes Mellitus? Evidence From Molecular Measures in a Diabetic Rat Model.
Other Title Info
Do The Dynamics of Insulin Delivery Matter for Management of Diabetes Mellitus? Evidence From Molecular Measures in a Diabetic Rat Model.