INSIG2 gene polymorphism is associated with increased subcutaneous fat in women and poor response to resistance training in men

Member of
FAU College Collections
Contributors
Orkunoglu-Suer, Funda E.
Gordish-Dressman, Heather
Clarkson, Priscilla M.
Thompson, Paul D.
Angelopoulos, Theodore J.
Gordon, Paul M.
Moyna, Niall M.
Pescatello, Linda S.
Visich, Paul S.
Zoeller, Robert F.
Harmon, Brennan
Seip, Richard L.
Hoffman, Eric P.
Devaney, Joseph M.
Date Issued
2008-12-23
Note

Background: A common SNP upstream of the INSIG2 gene, rs7566605 (g.-10,1025G>C,Chr2:118,552,255, NT_022135.15), was reported to be associated with obesity (Body Mass Index,[BMI]) in a genome-wide association scan using the Framingham Heart Study but has not been reproduced in other cohorts. As BMI is a relatively insensitive measure of adiposity that is subject to many confounding variables, we sought to determine the relationship between the INSIG2 SNPand subcutaneous fat volumes measured by MRI in a young adult population.

Language
English
Type
Text
Subject (Topical)
Adiposity --genetics
Alleles
Gene Frequency
Intracellular Signaling Peptides and Proteins
Resistance Training
Subcutaneous Fat
INSIG2 protein
Obesity
Genotype
Membrane proteins
Membrane Proteins --Genetics
Identifier
3327172
Additional Information
Background: A common SNP upstream of the INSIG2 gene, rs7566605 (g.-10,1025G>C,Chr2:118,552,255, NT_022135.15), was reported to be associated with obesity (Body Mass Index,[BMI]) in a genome-wide association scan using the Framingham Heart Study but has not been reproduced in other cohorts. As BMI is a relatively insensitive measure of adiposity that is subject to many confounding variables, we sought to determine the relationship between the INSIG2 SNPand subcutaneous fat volumes measured by MRI in a young adult population.
Date Backup
2008-12-23
Date Text
2008-12-23
DOI
10.1186/1471‐2350‐9‐117
Date Issued (EDTF)
2008-12-23
Extension


FAU
FAU
admin_unit="FAU01", ingest_id="ing11679", creator="creator:OCABEZAS", creation_date="2011-12-15 10:42:48", modified_by="super:SPATEL", modification_date="2013-05-28 13:21:09"

IID
FADT3327172
Person Preferred Name

Orkunoglu-Suer, Funda E.

creator

Physical Description

text/pdf[9p.]
PURL
http://purl.flvc.org/fcla/dt/3327172
Title Plain
INSIG2 gene polymorphism is associated with increased subcutaneous fat in women and poor response to resistance training in men
URL
http://purl.flvc.org/fcla/dt/3327172
Origin Information

2008-12-23
Title
INSIG2 gene polymorphism is associated with increased subcutaneous fat in women and poor response to resistance training in men
Other Title Info

INSIG2 gene polymorphism is associated with increased subcutaneous fat in women and poor response to resistance training in men