PRGMDH algorithm for neural network development and its applications

The existing Group Method of Data Handling (GMDH) algorithm has characteristics that are ideal for neural network design. This thesis introduces a new algorithm that applies some of the best characteristics of GMDH to neural network design and develops a Pruning based Regenerated Network by discarding the neurons in a layer which don't contribute for the creation of neurons in next layer. Unlike other conventional algorithms, which generate a network which is a black box, the new algorithm provides visualization of the network displaying all the neurons in the network. The algorithm is general enough that it will accept any number of inputs and any sized training set. To show the flexibility of the Pruning based Regenerated Network, this algorithm is used to analyze different combinations of drugs and determine which pathways in these networks interact and determine the combination of drugs that take advantage of these interactions to maximize a desired effect on genes.