Note
by Jonathan Moyes.
Member of
Contributors
Publisher
Florida Atlantic University
Date Issued
2012
Description
Alzheimer's disease (AD) is an increasingly common neurological disorder that mainly affects memory formation and retention. It is characterized by unique intercellular neurofibrillary tangles and extracellular beta-amyloid plaques. Histone deacetylase inhibitors (HDACi's) are competitive antagonists against histone deacetylases, causing histone acetyltransferases to acetylate the genome unregulated. This thesis investigates the use of new histone deacetylase inhibitors on recovering memory in a mouse model of Alzheimer's disease. By use of a fear conditioning paradigm, we have shown that these HDACI's increase memory in AD mice, but show either no effect or a positive effect in wild-type mice. Future experiments will investigate the efficacy of compound 966 and the spine density of hippocampal brain slices after fear conditioning trials.
Language
Type
Genre
Extent
[vii, 22] p. : ill.
Subject (Topical)
Identifier
819323184
OCLC Number
819323184
Rights
Copyright © is held by the author, with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder.
Additional Information
by Jonathan Moyes.
Unpaged volume.
Thesis (B.A.)--Florida Atlantic University, Honors College, 2012.
Includes bibliography.
Electronic reproduction. Boca Raton, Fla., 2012. Mode of access: World Wide Web.
Date Backup
2012
Date Text
2012
Date Issued (EDTF)
2012
Extension
FAU
FAU
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IID
FADT3359315
Issuance
multipart monograph
Organizations
Attributed name: Harriet L. Wilkes Honors College
Person Preferred Name
Moyes, Jonathan.
Physical Description
electronic
electronic resource
[vii, 22] p. : ill.
Title Plain
use of novel HDACi's for treatment of memory impairment in a mouse model of Alzheimer's disease
Use and Reproduction
Copyright © is held by the author, with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder.
Origin Information
2012
multipart monograph
Florida Atlantic University
Physical Location
FBoU FAUER
Title
use of novel HDACi's for treatment of memory impairment in a mouse model of Alzheimer's disease
Other Title Info
The
use of novel HDACi's for treatment of memory impairment in a mouse model of Alzheimer's disease