Note
Includes bibliography.
Member of
Contributors
Publisher
Florida Atlantic University
Date Issued
1997
EDTF Date Created
1997
Description
The bryostatins are a family of macrolide lactones isolated from the
marine bryozoan Bugu/a neritina. Since its detection in 1968, bryostatin 1
has demonstrated remarkable anticancer, immunopotentiating,
biomodulatory and radioprotective effects which result mainly from its
ability to activate protein kinase C, a family of isozymes involved in cellular
signal transduction. It is currently being tested in several phase I and phase
II clinical trials as a potential anticancer drug for leukemia, melanoma and
nephrotoma. A series of experiments was undertaken to elucidate the
biosynthetic origins of bryostatin, using a fortified crude cell-free enzyme
preparation and radiolabelled precursors. A regional characterization of
Bugula neritina from Sicily, Italy and Daytona Beach, Florida is also
described.
marine bryozoan Bugu/a neritina. Since its detection in 1968, bryostatin 1
has demonstrated remarkable anticancer, immunopotentiating,
biomodulatory and radioprotective effects which result mainly from its
ability to activate protein kinase C, a family of isozymes involved in cellular
signal transduction. It is currently being tested in several phase I and phase
II clinical trials as a potential anticancer drug for leukemia, melanoma and
nephrotoma. A series of experiments was undertaken to elucidate the
biosynthetic origins of bryostatin, using a fortified crude cell-free enzyme
preparation and radiolabelled precursors. A regional characterization of
Bugula neritina from Sicily, Italy and Daytona Beach, Florida is also
described.
Language
Type
Form
Extent
98 p.
Subject (Topical)
Identifier
FA00000787
Additional Information
Includes bibliography.
Thesis (M.S.)--Florida Atlantic University, 1997.
Charles E. Schmidt College of Science
Date Backup
1997
Date Created Backup
1997
Date Text
1997
Date Created (EDTF)
1997
Date Issued (EDTF)
1997
Extension
FAU
IID
FA00000787
Organizations
Attributed name: Florida Atlantic University
Attributed name: Charles E. Schmidt College of Science
Attributed name: Department of Chemistry and Biochemistry
Person Preferred Name
Lawry, Joseph
Graduate College
Physical Description
application/pdf
98 p.
Title Plain
Biosynthetic Studies of the Bryostatins, Anticancer Agents from the Marine Bryozoan Bugu/a neritina
Use and Reproduction
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Origin Information
1997
1997
Florida Atlantic University
Boca Raton, FL
Physical Location
Florida Atlantic University Libraries
Place
Boca Raton, FL
Sub Location
Digital Library
Title
Biosynthetic Studies of the Bryostatins, Anticancer Agents from the Marine Bryozoan Bugu/a neritina
Other Title Info
Biosynthetic Studies of the Bryostatins, Anticancer Agents from the Marine Bryozoan Bugu/a neritina