Model
Digital Document
Publisher
Florida Atlantic University
Description
The bryostatins are a family of macrolide lactones isolated from the
marine bryozoan Bugu/a neritina. Since its detection in 1968, bryostatin 1
has demonstrated remarkable anticancer, immunopotentiating,
biomodulatory and radioprotective effects which result mainly from its
ability to activate protein kinase C, a family of isozymes involved in cellular
signal transduction. It is currently being tested in several phase I and phase
II clinical trials as a potential anticancer drug for leukemia, melanoma and
nephrotoma. A series of experiments was undertaken to elucidate the
biosynthetic origins of bryostatin, using a fortified crude cell-free enzyme
preparation and radiolabelled precursors. A regional characterization of
Bugula neritina from Sicily, Italy and Daytona Beach, Florida is also
described.
marine bryozoan Bugu/a neritina. Since its detection in 1968, bryostatin 1
has demonstrated remarkable anticancer, immunopotentiating,
biomodulatory and radioprotective effects which result mainly from its
ability to activate protein kinase C, a family of isozymes involved in cellular
signal transduction. It is currently being tested in several phase I and phase
II clinical trials as a potential anticancer drug for leukemia, melanoma and
nephrotoma. A series of experiments was undertaken to elucidate the
biosynthetic origins of bryostatin, using a fortified crude cell-free enzyme
preparation and radiolabelled precursors. A regional characterization of
Bugula neritina from Sicily, Italy and Daytona Beach, Florida is also
described.
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