Stereochemical determination of dictyostatin, a novel microtubule-stabilising macrolide from the marine sponge Corallistidae sp.

The relative stereochemistry of the 22-membered marine macrolide dictyostatin, a Taxol-like antimitotic agent, was determined based on a combination of extensive high field NMR studies, including J-based configuration analysis, and molecular modelling.

Florida Atlantic University. Harbor Branch Oceanographic Institute contribution 1550

This manuscript is an author version with the final publication available and may be cited as: Paterson, I., Britton, R., Delgado, O., & Wright, A. E. (2004). Stereochemical determination of dictyostatin, a novel microtubule-stabilising macrolide from the marine sponge Corallistidae sp. Chemical Communications, (6), 632-633.