Skip to main content
fau.isle.flvc.org
User account menu
  • Log in

Breadcrumb

  1. Home

Tubulin Modulators

Total synthesis of a library of designed hybrids of the microtubule-stabilising anticancer agents taxol, discodermolide and dictyostatin

Model
Digital Document
Paterson, Ian
Naylor, G. J.
Fujita, T.
Guzman, Esther A.
Wright, Amy E.
Publisher
Royal Society of Chemistry.
Member of
HBOI Faculty Contributions

The microtubule-stabilizing agent discodermolide competitively inhibits the binding of paclitaxel (Taxol) to tubulin polymers, enhances tubulin nucleation reactions more potently than paclitaxel, and inhibits the growth of paclitaxel-resistant cells.

Model
Digital Document
Kowalski, R. J.
Giannakakou, P.
Gunasekera, Sarath P.
Longley, Ross E.
Day, B. W.
Hamel, E.
Publisher
American Society for Pharmacology and Experimental Therapeutics
Member of
HBOI Faculty Contributions

Stereochemical determination of dictyostatin, a novel microtubule-stabilising macrolide from the marine sponge Corallistidae sp.

Model
Digital Document
Paterson, Ian
Britton, R.
Delgado, Oscar
Wright, Amy E.
Publisher
Royal Society of Chemistry
Member of
HBOI Faculty Contributions

Total synthesis of a potent hybrid of the anticancer natural products dictyostatin and discodermolide.

Model
Digital Document
Paterson, Ian
Naylor, G. J.
Wright, Amy E.
Publisher
Royal Society of Chemistry
Member of
HBOI Faculty Contributions
Tubulin Modulators
RSS feed
Powered by Drupal