Total synthesis of a library of designed hybrids of the microtubule-stabilising anticancer agents taxol, discodermolide and dictyostatin

A hybrid library of the marine natural products dictyostatin and discodermolide, incorporating the taxol or taxotere side chains, were synthesised; preliminary biological evaluation in the PANC-1 cancer cell line revealed significant antiproliferative activity, demonstrating that a macrolide scaffold is an effective surrogate for the baccatin core of taxol.

Florida Atlantic University. Harbor Branch Oceanographic Institute contribution 1804

This manuscript is an author version with the final publication available and may be may be cited as: Paterson, I., Naylor, G. J., Fujita, T., Guzman, E., and Wright, A. E. (2010). Total synthesis of a library of designed hybrids of the microtubule-stabilising anticancer agents taxol, discodermolide and dictyostatin. Chemical Communications, 46(2), 261–263. doi:10.1039/b921237j