Total synthesis of a potent hybrid of the anticancer natural products dictyostatin and discodermolide.

Member of
HBOI Faculty Contributions
Contributors
Paterson, Ian
Naylor, G. J.
Wright, Amy E.
Publisher
Royal Society of Chemistry
Date Issued
2008
Note

A potent dictyostatin–discodermolide hybrid was designed and synthesised; it showed enhanced cell growth inhibitory activity relative to discodermolide in four human cancer cell lines including the Taxol-resistant NCI/ADR-Res cell line.

Language
English
Type
Text
Genre
article
Form
pdf
Extent
4 p.
Subject (Topical)
Antineoplastic agents
Macrolides
Polyketides
Tubulin Modulators
Marine natural products
Sponges
Identifier
FA00007062
Additional Information
A potent dictyostatin–discodermolide hybrid was designed and synthesised; it showed enhanced cell growth inhibitory activity relative to discodermolide in four human cancer cell lines including the Taxol-resistant NCI/ADR-Res cell line.
Florida Atlantic University. Harbor Branch Oceanographic Institute contribution 1776
This manuscript is an author version with the final publication available and may be cited as: Paterson, I., Naylor, G. J., & Wright, A. E. (2008). Total synthesis of a potent hybrid of the anticancer natural products dictyostatin and discodermolide. Chemical Communications, 38, 4628-4630. doi:10.1039/b811575c
Date Backup
2008
Date Text
2008
DOI
10.1039/b811575c
Date Issued (EDTF)
2008
Extension


FAU

IID
FA00007062
Person Preferred Name

Paterson, Ian
Physical Description

pdf
4 p.
PURL
http://purl.flvc.org/fau/fd/FA00007062
Title Plain
Total synthesis of a potent hybrid of the anticancer natural products dictyostatin and discodermolide.
URL
http://dx.doi.org/doi:10.1039/b811575c
Origin Information

2008
Royal Society of Chemistry

Cambridge

Place

Cambridge
Title
Total synthesis of a potent hybrid of the anticancer natural products dictyostatin and discodermolide.
Other Title Info

Total synthesis of a potent hybrid of the anticancer natural products dictyostatin and discodermolide.