Note
Includes bibliography.
Member of
Contributors
Publisher
Florida Atlantic University
Date Issued
2018
EDTF Date Created
2018
Description
The primary purpose of this study was to investigate the effects of aerobic and
resistance training on BDNF and IGF-I expression in a 3xTg-AD mouse model of
Alzheimer’s disease. Twenty-four 3xTg-AD mice were randomly assigned to either an
aerobic (AT, n=8), resistance (RT, n=8), or control (CNT, n=8) group. Intervention
groups underwent 9 weeks of exercise training. Motor behavior and grip strength were
measured pre- and post- intervention. Our results showed a significant increase in
hippocampal BDNF expression in AT mice after a 9-week intervention. Further, AT mice
were found to have higher concentrations of IGF-I, and improved motor behavior when
compared to RT and CNT. No significant differences were observed in IGF-I
concentration between RT and other groups. RT improved grip strength after nine weeks
of training. These findings support the use of AT and RT as a tool to improve
comorbidities found in Alzheimer’s disease.
resistance training on BDNF and IGF-I expression in a 3xTg-AD mouse model of
Alzheimer’s disease. Twenty-four 3xTg-AD mice were randomly assigned to either an
aerobic (AT, n=8), resistance (RT, n=8), or control (CNT, n=8) group. Intervention
groups underwent 9 weeks of exercise training. Motor behavior and grip strength were
measured pre- and post- intervention. Our results showed a significant increase in
hippocampal BDNF expression in AT mice after a 9-week intervention. Further, AT mice
were found to have higher concentrations of IGF-I, and improved motor behavior when
compared to RT and CNT. No significant differences were observed in IGF-I
concentration between RT and other groups. RT improved grip strength after nine weeks
of training. These findings support the use of AT and RT as a tool to improve
comorbidities found in Alzheimer’s disease.
Language
Type
Form
Extent
56 p.
Subject (Topical)
Identifier
FA00013094
Additional Information
Includes bibliography.
Thesis (M.S.)--Florida Atlantic University, 2018.
FAU Electronic Theses and Dissertations Collection
Date Backup
2018
Date Created Backup
2018
Date Text
2018
Date Created (EDTF)
2018
Date Issued (EDTF)
2018
Extension
FAU
IID
FA00013094
Organizations
Attributed name: Florida Atlantic University
Attributed name: College of Education
Attributed name: Department of Exercise Science and Health Promotion
Person Preferred Name
Pena, Gabriel S.
author
Graduate College
Physical Description
application/pdf
56 p.
Title Plain
Effects of Resistance and Aerobic Training on IGF-1 and BDNF Expression in a Murine Model of Alzheimer’s Disease
Use and Reproduction
Copyright © is held by the author, with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder.
http://rightsstatements.org/vocab/InC/1.0/
Origin Information
2018
2018
Florida Atlantic University
Boca Raton, Fla.
Physical Location
Florida Atlantic University Libraries
Place
Boca Raton, Fla.
Sub Location
Digital Library
Title
Effects of Resistance and Aerobic Training on IGF-1 and BDNF Expression in a Murine Model of Alzheimer’s Disease
Other Title Info
Effects of Resistance and Aerobic Training on IGF-1 and BDNF Expression in a Murine Model of Alzheimer’s Disease