Note
Includes bibliography.
Member of
Contributors
Publisher
Florida Atlantic University
Date Issued
2017
EDTF Date Created
2017
Description
Aging is the result of the progressive and intrinsic accumulation of detrimental changes in an organism over time. Understanding the molecular pathways that contribute to aging is critical for the development of therapeutic agents to treat age-related disorders. As an animal ages, it accumulates senescent cells, cells that are unable to grow or divide but remain metabolically active. They secrete Senescence Associated Secretory Phenotype (SASP) factors, which can disrupt tissue and cause age related diseases. The Ercc1-/Δ mice are an accelerated aging, progeriod model, and thus it was hypothesized that cellular senescence would increase in the Ercc1-/Δ mice. Through quantitative polymerase chain reaction (qPCR) analysis, the expression of senescence biomarkers p16INK4a, p21, IL-6 and TNF-α were measured to confirm that Ercc1-/Δ mice do experience an increase in cellular senescence. Additionally, we were able to determine that there are gender differences regarding the accumulation of senescent cells in various body parts.
Language
Type
Genre
Form
Extent
38 p.
Identifier
FA00012609
Additional Information
Includes bibliography.
Thesis (B.A.)--Florida Atlantic University, Harriet L. Wilkes Honors College, 2017.
FAU Honors Theses Digital Collection
Date Backup
2017
Date Created Backup
2017
Date Text
2017
Date Created (EDTF)
2017
Date Issued (EDTF)
2017
Extension
FAU
IID
FA00012609
Organizations
Attributed name: Florida Atlantic University
Attributed name: Harriet L. Wilkes Honors College
Person Preferred Name
Bukata, Christina
author
Physical Description
application/pdf
38 p.
Title Plain
CELLULAR SENESCENCE INCREASES IN THE ERCC1-/Δ MOUSE MODEL OF ACCELERATED AGING
Use and Reproduction
Copyright © is held by the author with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder.
Origin Information
2017
2017
Florida Atlantic University
Jupiter, Florida
Physical Location
Florida Atlantic University Libraries
Place
Jupiter, Florida
Sub Location
Digital Library
Title
CELLULAR SENESCENCE INCREASES IN THE ERCC1-/Δ MOUSE MODEL OF ACCELERATED AGING
Other Title Info
CELLULAR SENESCENCE INCREASES IN THE ERCC1-/Δ MOUSE MODEL OF ACCELERATED AGING