electronic resource

The Free Press at Florida Atlantic University was published from 1994 to 1995. This newspaper consists of 7 volumes arranged in volume order.

Prostate cancer is one of the leading causes of death in men aged 40-55. Genistein isoflavone (4', 5', 7-trihydroxyisoflavone) is a dietary phytochemical with demonstrated anti-tumor activities in a variety of cancers. Topotecan Hydrochloride (Hycamtin) is an FDA-approved chemotherapy drug, primarily used for secondary treatment of ovarian,cervical and small cell lung cancers. This study was to demonstrate the potential anticancer activities and synergy of topotecan-genistein combination in LNCaP prostate cancer cells. The potential efficacy and mechanism of topotecan/genistein-induced cell death was investigated... Results: The overall data indicated that i) both genistein and topotecan induce cellular death in LNCaP cells, ii) topotecan-genistein combination was significantly more efficacious in reducing LNCaP cell viabiligy compared to either genistein or topotecan alone, iii) in all cases, cell death was primarily through apoptosis, via the activation of the intrinsic pathway, iv) ROS levels were increased and VEGF expression was diminished significantly with the topotecan-genistein combination treatment, v) genetic analysis of topotecan-genistein treatment groups showed changes in genetic expression levels in pathway specific apoptotic genes.... Conclusion: Treatments involving topotecan-genistein combination may prove to be an attractive alternative phytotherapy of adjuvant therapy for prostate cancer.

The focus of this thesis is to develop lanthanide (Ln) luminescent materials through the exploration of coordination polymers and nanomaterials. Herein, dimethyl-3,4- furanedicarboxylate acid undergoes hydrolysis under hydrothermal conditions to form coordination polymers with lanthanide ions. The resulting coordination polymers exhibited luminescent properties, with quantum yields and lifetimes for the Eu-and Tb-CP of 1.14+-0.32% and 0.387=-0.0001 mx, and 3.33=-0.82% and 0.769=-0.006 ms, respectively. While the incorporation of lanthanides was not achieved in this work, progress toward the production of pure phase InP in the nanoregime has been made, using a low-cost, hydrothermal method. Through SEM and PXRD conflict, it is believed that pure INP particles with a size range of 58-81 nm were successfully synthesized.

This thesis discusses the coupling of a mechanical and electrical oscillator, an arrangement that is often encountered in mechatronics actuators and sensors. The dynamics of this coupled system is mathematically modeled and a low pass equivalent model is presented. Numerical simulations are then performed, for various input signals to characterize the nonlinear relationship between the electrical current and the displacement of the mass. Lastly a framework is proposed to estimate the mass position without the use of a position sensor, enabling the sensorless control of the coupled system and additionally providing the ability for the system to act as an actuator or a sensor. This is of value for health monitoring, diagnostics and prognostics, actuation and power transfer of a number of interconnected machines that have more than one electrical system, driving corresponding mechanical subsystems while being driven by the same voltage source and at the same time being spectrally separated and independent.

The lens is an avascular organ that focuses light onto the retina where neural signals are transmitted to the brain and translated into images. Lens transparency is vital for maintaining function. The lens is formed through a transition from organelle-rich epithelial cells to organelle-free fiber cells. Lens cell differentiation, leading to the lack of organelles, provides an environment optimal for minimizing light scatter and maximizing the ability to focus light onto the retina. The process responsible for orchestrating lens cell differentiation has yet to be elucidated. In recent years, data has emerged that led our lab to hypothesize that autophagy is likely involved in lens cell maintenance, cell differentiation, and maintenance of lens transparency. As a first step towards testing this hypothesis, we used RT-PCR, western blot analysis, immunohistochemistry, confocal microscopy, and next generation RNA-Sequencing (RNA-Seq) to examine autophagy genes expressed by the lens to begin mapping their lens function.

The current study is a content analysis and comparison of news articles from the New York Times and the Wall Street Journal. The objective of this study is to explore media coverage of terrorism over the last five decades to determine the impact of religion and to compare coverage between two respected news sources that are known for their liberal (New York Times) and conservative (Wall Street Journal) view points. Using a stratified random sample, 1,832 news articles were selected between 1960 and 2006 from the two news sources of interest. The articles were read, analyzed, and categorized. Then, a qualitative analysis examined a random selection of articles pertaining to religious terrorist events. Results suggest an increase in coverage of religiously perpetrated terrorism in recent decades. Interestingly, coverage from the New York Times and the Wall Street Journal showed similar patterns despite being representative of opposite ideologies. Implications are discussed.

Here, the natural world is consumed - a physical reality and an internal one. It is walled, but roofless - a contained space. Elements are absorbed, same energies interacting within us that work around us - the natural forces of gravitation and electromagnetism, fire and water, growth, and time. Fundamental interactions in nature, forces that hold the universe together are treated as symbolic of the human experience. The sense of rooflessness is an essential theme to my thesis. There is a constant return to the sky. The shifting clouds, the stages of the sun and the moon mimic a traveling through time, a constant change. There is a given feeling of freedom and confinement. There is a vulnerability, a destitution, and a lack of shelter. The open sky, always out of reach, is a tease to be free. Though it also hints at a feeling of oneness, a symbolic relation between the divine and the human. The open, uninterrupted path for direct prayer. Roofless indicates a continuous linkage between the ground and the sky, between rain and dirt, between nature and humankind. .

This study uses Karlyn Campbell's concept of feminine rhetorical style as a theoretical framework for analyzing the rhetoric of Barbara Bush's 1990 Wellesley College commencement address. Through a systematic evaluation of Barbara Bush's speech, this study reveals that her rhetoric exemplifies feminine rhetorical style. The analysis also concludes that Barbara Bush's personal tone, specifically her use of narrative and humor, is the most useful and effective characteristic of her feminine rhetorical style. Using feminine rhetorical style, Barbara Bush successfully dissipates some of the tension she faced prior to the graduation ceremony at Wellesley College. Therefore, this study reveals that feminine rhetorical style is an attractive alternative for speakers seeking to build identification in hostile situations when identification is, or appears to be, lacking.

This research examines the U.S. media during the 1999 Women's World Cup from a feminist postcolonial standpoint. This research adds to current feminist scholarship on women and sports by de-centering the global North in its discourse. It reveals the bias of the media through the representation of the United States National Team as a universal "woman" athlete and the standard for international women's soccer. It further argues that, as a result, the Nigerian National Team was cast in simplistic stereotypes of race, class, ethnicity, and nation, which were often also appropriated and commodified. I emphasize that the Nigerian National Team resisted this construction and fought to secure their position in the global soccer landscape. I conclude that these biased representations, which did not fairly depict or value the contributions of diverse competing teams, were primarily employed to promote and sell the event to a predominantly white middle-class American audience.

RNA damage occurring under oxidative stress has been shown to cause RNA dysfunction and must be detrimental to cells and organisms. We propose that damaged RNA can be removed by specific RNA surveillance activities. In this work, we investigated the role of polynucleotide phosphorylase (PNPase), a 3'->5' exoribonuclease, in protecting the cells against oxidative stress and eliminating oxidatively-damaged RNA. Previously, it was reported that E. coli PNPase has a higher affinity to poly(8-oxoG:A). We further confirmed that E. coli PNPase can specifically bind to an oxidized RNA with a high affinity. An E. coli strain deficient in PNPase (pnp) is hypersensitive to hydrogen peroxide (H2O2). Importantly, the level of H2O2-induced RNA damage, measured by the content of 8-hydroxyguanosine, increases significantly in the pnp mutant cells. Consistent with the notion that PNPase plays a direct role in these processes, introduction of the pnp gene encoding E. coli PNPase can restore the viability and RNA oxidation level of the pnp mutant cells in response to H2O2 treatment. Interestingly, degradosome-association is not required for PNPase to protect cell against oxidative stress. PNPase is evolutionary conserved in most of organisms of all domains of life. The human polynucleotide phosphorylase (hPNPase) localizes mainly in mitochondria and plays pleiotropic roles in cell differentiation and has been previously shown to bind 8- oxoG-RNA with a high affinity. Here we show that similar to E. coli PNPase, hPNPase plays an indispensable role in protecting HeLa cells against oxidative stress. The viability in HeLa cell and 8-oxoG levels in RNA are inversely correlated in response to H2O2- treatment. After removal of oxidative challenge, the elevated level of 8-oxoG in RNA decreases, suggesting the existence of surveillance mechanism(s) for cleaning up oxidized RNA.