Model
Digital Document
Publisher
Florida Atlantic University Digital Library
Description
In organic synthesis, the phase-vanishing (PV) technique uses an organofluoride solution to keep two reactive solutions in separate layers, while allowing a reaction to
proceed at the interface of the fluorous layer. PV reactions allow otherwise vigorous
reactions to proceed at a slower, more controlled rate. In this research, we evaluated the use of PTFE tape as a phase screen in the synthesis of chiral α-halo ethers and acetals. We were successful in synthesizing the two compounds of interest, and also successful in their isolation through the use of column chromatography. Since α-halo ethers are known to be carcinogenic, the use of PTFE tape minimizes exposure to the potentially harmful substance.
proceed at the interface of the fluorous layer. PV reactions allow otherwise vigorous
reactions to proceed at a slower, more controlled rate. In this research, we evaluated the use of PTFE tape as a phase screen in the synthesis of chiral α-halo ethers and acetals. We were successful in synthesizing the two compounds of interest, and also successful in their isolation through the use of column chromatography. Since α-halo ethers are known to be carcinogenic, the use of PTFE tape minimizes exposure to the potentially harmful substance.
Member of