Thakkar, Jay.

During the Leukocytapheresis (LCAP) process used to treat patients suffering from acute Ulcerative Colitis, medical practitioners have to continuously monitor the Hematocrit (Ht) level in the blood to ensure it is within the acceptable range. The work done, as a part of this thesis, attempts to create an early warning system that can be used to predict if and when the Ht values will deviate from the acceptable range. To do this we have developed an algorithm based on the Group Method of Data Handling (GMDH) and compared it to other Neural Network algorithms, in particular the Multi Layer Perceptron (MLP). The standard GMDH algorithm captures the fluctuation very well but there is a time lag that produces larger errors when compared to MLP. To address this drawback we modified the GMDH algorithm to reduce the prediction error and produce more accurate results.