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Research examining immune function during obesity suggests that excessive adiposity is linked to impaired immune responses
leading to pathology.Thedeleterious effects of obesity on immunity have been associated with the systemic proinflammatory profile
generated by the secretory molecules derived from adipose cells. These include inflammatory peptides, such as TNF-𝛼, CRP, and
IL-6. Consequently, obesity is now characterized as a state of chronic low-grade systemic inflammation, a condition considerably
linked to the development of comorbidity. Given the critical role of adipose tissue in the inflammatory process, especially in obese
individuals, it becomes an important clinical objective to identify lifestyle factors that may affect the obesity-immune system
relationship. For instance, stress, physical activity, and nutrition have each shown to be a significant lifestyle factor influencing
the inflammatory profile associated with the state of obesity.Therefore, the purpose of this review is to comprehensively evaluate
the impact of lifestyle factors, in particular psychological stress, physical activity, and nutrition, on obesity-related immune function
with specific focus on inflammation.
leading to pathology.Thedeleterious effects of obesity on immunity have been associated with the systemic proinflammatory profile
generated by the secretory molecules derived from adipose cells. These include inflammatory peptides, such as TNF-𝛼, CRP, and
IL-6. Consequently, obesity is now characterized as a state of chronic low-grade systemic inflammation, a condition considerably
linked to the development of comorbidity. Given the critical role of adipose tissue in the inflammatory process, especially in obese
individuals, it becomes an important clinical objective to identify lifestyle factors that may affect the obesity-immune system
relationship. For instance, stress, physical activity, and nutrition have each shown to be a significant lifestyle factor influencing
the inflammatory profile associated with the state of obesity.Therefore, the purpose of this review is to comprehensively evaluate
the impact of lifestyle factors, in particular psychological stress, physical activity, and nutrition, on obesity-related immune function
with specific focus on inflammation.
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