Model
Digital Document
Publisher
Florida Atlantic University
Description
Sox proteins all contain a single ~70 amino acid High Mobility Group (HMG)
DNA-binding domain with strong homology to that of Sry, the mammalian testisdetermining
factor. In Drosophila melanogaster, there are four closely related members
of the B group, Dichaete (D), Sox Neuro (Sox N), Sox 21a, and Sox 21b that each exhibit
~90% sequence identity within the HMG domain.The previous study has shown that
Dichaete plays a major role in embryonic nervous system development and is expressed
in several clusters of neurons in the brain, including intermingled olfactory LNs and
central-complex neurons strongly expressed in local interneuron of the olfactory system.
However, little is known about the possible expression and functions of the related group
B Sox genes in the larval and adult brain. In particular, it is unclear if Sox N may
function along with Dichaete in controlling the development or physiology of the adult
olfactory system. Our data suggests Sox N potential role in the elaboration of the
olfactory circuit formation.
DNA-binding domain with strong homology to that of Sry, the mammalian testisdetermining
factor. In Drosophila melanogaster, there are four closely related members
of the B group, Dichaete (D), Sox Neuro (Sox N), Sox 21a, and Sox 21b that each exhibit
~90% sequence identity within the HMG domain.The previous study has shown that
Dichaete plays a major role in embryonic nervous system development and is expressed
in several clusters of neurons in the brain, including intermingled olfactory LNs and
central-complex neurons strongly expressed in local interneuron of the olfactory system.
However, little is known about the possible expression and functions of the related group
B Sox genes in the larval and adult brain. In particular, it is unclear if Sox N may
function along with Dichaete in controlling the development or physiology of the adult
olfactory system. Our data suggests Sox N potential role in the elaboration of the
olfactory circuit formation.
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