Biophysics

Dose uniformity in the Planning Target Volume (PTV) can induce a higher-than-expected dose distribution in the nearby critical organs. The goal of this study is to evaluate the influence of the Planning Target volume dose uniformity on the surrounding critical organs (OAR).
Ten cases of anonymized patients’ data were selected for our study including: Breast cancer, Brain cancer, Head and Neck cancer, Lung and Prostate calculations of Conformity indices, Biological Effective Doses (BED), Tumor Control Probability (TCP) and Normal Tissue Complication Probability (NTCP) were used to calculate the dose distribution in PTV as well as the dose delivered to the surrounding critical organs of each PTV. We assume that the tumors PTVs have homogeneous density as well as the surrounding normal tissue.
Conformity indices (CI) for Breast (PTV) are between 1.8 – 1.9, for Brain (PTV) are between 1.6 – 2.0, for Lungs are 1.5 – 1.6, for Prostate are between 0.4 – 0.5, for Head and Neck are 0.3 – 0.4. Dose uniformity in all the PTVs is 1.089 which is a good indication of the quality of treatment delivered to the tumor. TCP is averaging of value of 87.94 and NTCP is 3.4445.

In this work a bio-inspired flapping actuator based on varied magnetic fields is
developed, controlled and characterized. The actuator is sought to contribute to the
toolbox of options for bio-mimetics research. The design is that of a neodymium bar
magnet on one end of an armature which is moved by two air core electromagnetic coils
in the same manner as agonist and antagonist muscle pairs function in biological systems.
The other end of the armature is fitted to a rigid fin extending beyond the streamline
enclosure body to produce propulsion. A series of tests in still water were performed to
measure the kinematics and propulsive force for different control schemes including the
effect of adding antagonistic resistance to the control schemes. Control methods based on
armature position and based on setpoint error were tested and antagonist force was found
to increase consistency of control of the systems in certain cases.